{"id":22,"date":"2024-06-06T18:04:56","date_gmt":"2024-06-06T18:04:56","guid":{"rendered":"https:\/\/stgbeyond9.wpenginepowered.com\/?page_id=22"},"modified":"2026-05-25T13:49:13","modified_gmt":"2026-05-25T13:49:13","slug":"hcp","status":"publish","type":"page","link":"https:\/\/hemophilia-beyond-9.com\/pt-br\/hcp\/","title":{"rendered":"Para profissionais de sa\u00fade"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"22\" class=\"elementor elementor-22\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8afc29f header-background e-flex e-con-boxed e-con e-parent\" data-id=\"8afc29f\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-1c1aceb e-flex e-con-boxed e-con e-child\" data-id=\"1c1aceb\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f9db144 elementor-widget elementor-widget-heading\" data-id=\"f9db144\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Cuidando de pacientes com hemofilia B?<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1e4687c elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"1e4687c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>Converse com seus pacientes sobre o BEYOND-9<\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6edad58 elementor-mobile-align-center button-one elementor-widget elementor-widget-button\" data-id=\"6edad58\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"http:\/\/www.clinicaltrials.gov\/study\/NCT06379789\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Clinicaltrials.gov<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-09cc1f6 button-two elementor-widget elementor-widget-button\" data-id=\"09cc1f6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/euclinicaltrials.eu\/search-for-clinical-trials\/?lang=en&#038;EUCT=2023-507260-40-00\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">euclinicaltrials.eu<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-26eb911 e-flex e-con-boxed e-con e-child\" data-id=\"26eb911\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c08ea34 background-left e-flex e-con-boxed e-con e-parent\" data-id=\"c08ea34\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c89555c e-con-full e-flex e-con e-child\" data-id=\"c89555c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6019c2d elementor-widget elementor-widget-image\" data-id=\"6019c2d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"298\" height=\"244\" src=\"https:\/\/hemophilia-beyond-9.com\/wp-content\/uploads\/2024\/08\/HCPFirst.svg\" class=\"attachment-full size-full wp-image-263\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d24850f e-con-full e-flex e-con e-child\" data-id=\"d24850f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5e2030f elementor-widget elementor-widget-text-editor\" data-id=\"5e2030f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tSem uma cura para a hemofilia B, o estudo cl\u00ednico BEYOND-9 est\u00e1 em andamento para investigar op\u00e7\u00f5es de tratamento a longo prazo que possam beneficiar tanto adultos quanto crian\u00e7as. Considere o BEYOND-9 como uma oportunidade para seus pacientes com hemofilia B terem acesso a tratamentos investigacionais.\n\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-13b7af5 elementor-widget elementor-widget-text-editor\" data-id=\"13b7af5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tO BEYOND-9 \u00e9 um estudo cl\u00ednico de fase 1\/2, testado pela primeira vez em humanos (FIH), que busca avaliar a seguran\u00e7a, tolerabilidade, farmacocin\u00e9tica (PK) e farmacodin\u00e2mica (PD) de um tratamento investigacional em participantes com hemofilia B cong\u00eanita grave e moderadamente grave com atividade funcional de FIX \u22642%.\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-660ab70 e-flex e-con-boxed e-con e-parent\" data-id=\"660ab70\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-32d55b6 elementor-widget elementor-widget-text-editor\" data-id=\"32d55b6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tO tratamento do estudo \u00e9 uma terapia investigacional de inser\u00e7\u00e3o g\u00eanica com base em repeti\u00e7\u00f5es palindr\u00f4micas curtas agrupadas e regularmente intercaladas (CRISPR)\/prote\u00edna associada ao CRISPR 9 (Cas9). \u00c9 composto por 2 componentes a serem administrados como uma infus\u00e3o intravenosa sist\u00eamica \u00fanica e sequencial.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a7757b3 e-flex e-con-boxed e-con e-parent\" data-id=\"a7757b3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3959521 e-flex e-con-boxed e-con e-child\" data-id=\"3959521\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-41f48f4 e-flex e-con-boxed e-con e-child\" data-id=\"41f48f4\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3296e49 elementor-widget elementor-widget-image\" data-id=\"3296e49\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"102\" height=\"102\" src=\"https:\/\/hemophilia-beyond-9.com\/wp-content\/uploads\/2024\/08\/One.svg\" class=\"attachment-full size-full wp-image-218\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b724cb8 e-flex e-con-boxed e-con e-child\" data-id=\"b724cb8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ff3412f elementor-widget elementor-widget-text-editor\" data-id=\"ff3412f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><span><\/span><\/strong> O <b>Componente 1 (REGV131)<\/b> cont\u00e9m um gene de DNA do F9 sem promotor, que codifica a prote\u00edna FIX humana do tipo selvagem, fornecido utilizando o v\u00edrus adeno-associado recombinante de sorotipo 8 (rAAV8). O modelo de DNA do F9 \u00e9 inserido no local onde ocorreu a quebra da fita dupla de DNA (DSB) e \u00e9 transcrito sob a influ\u00eancia do promotor end\u00f3geno Albumina (ALB), resultando na express\u00e3o e secre\u00e7\u00e3o da prote\u00edna FIX humana selvagem pelo f\u00edgado.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f434fc2 e-con-full e-flex e-con e-child\" data-id=\"f434fc2\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-af16cda elementor-widget elementor-widget-image\" data-id=\"af16cda\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"102\" height=\"102\" src=\"https:\/\/hemophilia-beyond-9.com\/wp-content\/uploads\/2024\/08\/Two.svg\" class=\"attachment-full size-full wp-image-219\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-839173b e-flex e-con-boxed e-con e-child\" data-id=\"839173b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-864a6d5 elementor-widget elementor-widget-text-editor\" data-id=\"864a6d5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><span><\/span><\/strong> O <b>Componente 2 (LNP1265)<\/b> utiliza uma tecnologia modular de nanopart\u00edculas lip\u00eddicas (LNP) para fornecer o RNA guia simples (sgRNA) que direciona \u00e0 ALB e o mRNA que codifica a endonuclease Cas9 guiada por RNA aos hepat\u00f3citos, permitindo a introdu\u00e7\u00e3o de uma DSB espec\u00edfica do local no primeiro \u00edntron do locus ALB.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6dc33b2 resourcepdf e-flex e-con-boxed e-con e-parent\" data-id=\"6dc33b2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3627afd e-grid e-con-full e-con e-child\" data-id=\"3627afd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3fd4e8c elementor-widget elementor-widget-heading\" data-id=\"3fd4e8c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Saiba mais<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7a141d9 e-con-full e-flex e-con e-child\" data-id=\"7a141d9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-722e898 elementor-widget elementor-widget-image\" data-id=\"722e898\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"#elementor-action%3Aaction%3Dpopup%3Aopen%26settings%3DeyJpZCI6IjQwMiIsInRvZ2dsZSI6ZmFsc2V9\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1183\" height=\"678\" src=\"\/wp-content\/uploads\/2026\/05\/HCP_Brazil.jpg\" class=\"attachment-full size-full wp-image-461\" alt=\"\" srcset=\"\" sizes=\"(max-width: 1183px) 100vw, 1183px\" data-srcset=\"\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b56a55f elementor-align-center elementor-mobile-align-center elementor-widget elementor-widget-button\" data-id=\"b56a55f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/wp-content\/uploads\/2026\/05\/HSCI-P00102043-HCP-Infographic-16_pt-BR-1.pdf\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Fa\u00e7a o download<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-39407ae background-right e-flex e-con-boxed e-con e-parent\" data-id=\"39407ae\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-dfc2dd5 e-con-full e-flex e-con e-child\" data-id=\"dfc2dd5\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3c6c31b elementor-widget elementor-widget-text-editor\" data-id=\"3c6c31b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tEspera-se que os pacientes participem deste estudo por at\u00e9 aproximadamente 2 anos e 8 meses. A participa\u00e7\u00e3o pode durar mais tempo (at\u00e9 4 anos e 2 meses) dependendo do tempo dedicado ao per\u00edodo inicial.\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38e0e7b elementor-widget elementor-widget-text-editor\" data-id=\"38e0e7b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tOs participantes ser\u00e3o reembolsados por despesas razo\u00e1veis de viagem de ida e volta para as visitas do estudo, e os cuidados m\u00e9dicos relacionados \u00e0 sua participa\u00e7\u00e3o, incluindo o tratamento do estudo, ser\u00e3o fornecidos gratuitamente. \n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e399a6c button-three elementor-mobile-align-center elementor-widget elementor-widget-button\" data-id=\"e399a6c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/pt-br\/about-beyond-9\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Sobre o BEYOND-9<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c57d058 e-con-full e-flex e-con e-child\" data-id=\"c57d058\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-386f258 elementor-widget elementor-widget-image\" data-id=\"386f258\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"470\" height=\"319\" src=\"https:\/\/hemophilia-beyond-9.com\/wp-content\/uploads\/2024\/08\/HCPAbout.svg\" class=\"attachment-full size-full wp-image-264\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-058138c e-flex e-con-boxed e-con e-parent\" data-id=\"058138c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-96593d7 elementor-widget elementor-widget-heading\" data-id=\"96593d7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Como voc\u00ea pode ajudar?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3948946 elementor-widget elementor-widget-text-editor\" data-id=\"3948946\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tO estudo BEYOND-9 est\u00e1 inscrevendo at\u00e9 cerca de 120 pessoas em cerca de 10 pa\u00edses. O sucesso do BEYOND-9 depende da indica\u00e7\u00e3o de potenciais participantes para o estudo, por parte dos m\u00e9dicos. Confira os principais crit\u00e9rios do estudo abaixo para ajudar a identificar potenciais participantes.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-eb26836 e-flex e-con-boxed e-con e-parent\" data-id=\"eb26836\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3718095 e-flex e-con-boxed e-con e-child\" data-id=\"3718095\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-b556b2d e-flex e-con-boxed e-con e-child\" data-id=\"b556b2d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c65d268 elementor-widget elementor-widget-image\" data-id=\"c65d268\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"76\" height=\"77\" src=\"https:\/\/hemophilia-beyond-9.com\/wp-content\/uploads\/2024\/08\/Tick.svg\" class=\"attachment-full size-full wp-image-222\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-46c7386 e-flex e-con-boxed e-con e-child\" data-id=\"46c7386\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f55b0ea elementor-widget elementor-widget-heading\" data-id=\"f55b0ea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Principais crit\u00e9rios de inclus\u00e3o:<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7eff5ff ul-only elementor-widget elementor-widget-text-editor\" data-id=\"7eff5ff\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Homem (\u226518 anos de idade)<br \/>OBSERVA\u00c7\u00c3O: A inclus\u00e3o de pacientes pedi\u00e1tricos no ensaio cl\u00ednico [(entre 2 e 17 anos de idade)] \u00e9 uma previs\u00e3o futura<\/li><li>Diagn\u00f3stico confirmado de hemofilia B grave ou moderadamente grave, com hist\u00f3rico m\u00e9dico de atividade funcional de FIX \u22642% ou &lt;0,02 UI\/ml<\/li><li>Atualmente em profilaxia com FIX e experi\u00eancia pr\u00e9via com terapia de FIX: \u2265150 dias de exposi\u00e7\u00e3o documentados a um produto de prote\u00edna FIX, como produtos recombinantes, derivados de plasma ou de meia-vida prolongada<\/li><li>Participa\u00e7\u00e3o no per\u00edodo inicial deste estudo intervencional OU em um estudo inicial separado (R0000-HEMB-2187) por pelo menos 6 meses para coleta de dados de ABR enquanto em profilaxia com FIX.<br \/>OBSERVA\u00c7\u00c3O: Os primeiros 3 participantes inclu\u00eddos na Parte 1 do estudo n\u00e3o s\u00e3o obrigados a participar do per\u00edodo inicial<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d32c571 e-con-full e-flex e-con e-child\" data-id=\"d32c571\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ac78d28 elementor-widget elementor-widget-image\" data-id=\"ac78d28\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"76\" height=\"76\" src=\"https:\/\/hemophilia-beyond-9.com\/wp-content\/uploads\/2024\/08\/X.svg\" class=\"attachment-full size-full wp-image-223\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e4c2313 e-flex e-con-boxed e-con e-child\" data-id=\"e4c2313\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f29b377 elementor-widget elementor-widget-heading\" data-id=\"f29b377\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Principais crit\u00e9rios de exclus\u00e3o:<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-636ec4e ul-only elementor-widget elementor-widget-text-editor\" data-id=\"636ec4e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<style>.elementor-element-636ec4e{display:none !important}<\/style>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cc747bc ul-only elementor-widget elementor-widget-text-editor\" data-id=\"cc747bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul>\n \t<li>Hist\u00f3rico de inibidor de FIX (avalia\u00e7\u00e3o cl\u00ednica ou laboratorial) em 2 ou mais ocasi\u00f5es<\/li>\n \t<li>Titula\u00e7\u00e3o de inibidor de Bethesda maior que o limite superior da normalidade (LSN) na triagem\u202f\u202f <\/li>\n \t<li>Anticorpos pr\u00e9-existentes detect\u00e1veis contra o caps\u00eddeo AAV8, conforme medido por ELISA na pr\u00e9-triagem (ou na visita final do per\u00edodo inicial, se aplic\u00e1vel)<\/li>\n \t<li>Um participante n\u00e3o \u00e9 eleg\u00edvel se qualquer um dos seguintes diagn\u00f3sticos pr\u00e9-existentes, indicativos de doen\u00e7a hep\u00e1tica subjacente significativa, estiver documentado:\u202f\u202f \n<ul>\n \t<li>Doen\u00e7a hep\u00e1tica colest\u00e1tica<\/li>\n \t<li>Cirrose hep\u00e1tica\u202f\u202f <\/li>\n \t<li>Hipertens\u00e3o portal<\/li>\n \t<li>Esplenomegalia\u202f\u202f <\/li>\n \t<li>Encefalopatia hep\u00e1tica<\/li>\n<\/ul>\n<\/li>\n \t<li>Evid\u00eancia de fibrose hep\u00e1tica avan\u00e7ada sugestiva de igual ao Est\u00e1gio 3 METAVIR na triagem (ou seja, medi\u00e7\u00e3o de rigidez hep\u00e1tica \u22659 kPa), conforme medido por elastografia transit\u00f3ria (FibroScan) na triagem ou medida dentro de 6 meses antes da visita de triagem <\/li>\n \t<li>Evid\u00eancia de cirrose e\/ou hipertens\u00e3o portal conforme avaliado por ultrassonografia hep\u00e1tica na triagem ou medida dentro de 6 meses antes da visita de triagem<\/li>\n \t<li>Hist\u00f3rico de eventos tromboemb\u00f3licos arteriais ou venosos, incluindo, entre outros, acidente vascular cerebral n\u00e3o hemorr\u00e1gico, infarto do mioc\u00e1rdio, \u00eambolo arterial, trombose venosa profunda, embolia pulmonar, com exce\u00e7\u00e3o da trombose associada a cateter para a qual o tratamento antitromb\u00f3tico n\u00e3o est\u00e1 atualmente em andamento <\/li>\n \t<li>Hist\u00f3rico de hipersensibilidade a corticosteroides ou condi\u00e7\u00e3o m\u00e9dica conhecida \n\nque requer administra\u00e7\u00e3o cr\u00f4nica de corticosteroides  <\/li>\n \t<li>Recebimento pr\u00e9vio de qualquer terapia g\u00eanica baseada em AAV com uma terapia g\u00eanica comercializada ou em um estudo cl\u00ednico, ou inten\u00e7\u00e3o de receber terapia g\u00eanica baseada em AAV aprovada ou investigacional diferente do tratamento do estudo durante o per\u00edodo do estudo<\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3e8c3e4 e-flex e-con-boxed e-con e-parent\" data-id=\"3e8c3e4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3458326 e-con-full e-flex e-con e-child\" data-id=\"3458326\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9c046b0 elementor-widget elementor-widget-image\" data-id=\"9c046b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"94\" height=\"137\" src=\"https:\/\/hemophilia-beyond-9.com\/wp-content\/uploads\/2024\/08\/HCPicon.svg\" class=\"attachment-full size-full wp-image-245\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-07d7d1f e-flex e-con-boxed e-con e-child\" data-id=\"07d7d1f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2406c67 elementor-widget elementor-widget-text-editor\" data-id=\"2406c67\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Aten\u00e7\u00e3o:<\/strong> Outros crit\u00e9rios de inclus\u00e3o\/exclus\u00e3o definidos pelo protocolo se aplicam.\u202f\u202f\u00a0\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1939f17 elementor-widget elementor-widget-text-editor\" data-id=\"1939f17\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A equipe far\u00e1 a an\u00e1lise do hist\u00f3rico m\u00e9dico completo dos pacientes para verificar se eles atendem a todos os crit\u00e9rios de inclus\u00e3o e a nenhum dos crit\u00e9rios de exclus\u00e3o. A diversidade em estudos cl\u00ednicos \u00e9 fundamental para desenvolver melhores tratamentos \u2013 ajude a garantir que seus pacientes sejam representados.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ce474a4 e-flex e-con-boxed e-con e-parent\" data-id=\"ce474a4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-679f051 e-flex e-con-boxed e-con e-child\" data-id=\"679f051\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fea662c elementor-widget elementor-widget-text-editor\" data-id=\"fea662c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tSe voc\u00ea tiver pacientes potencialmente eleg\u00edveis e interessados, capacite-os com op\u00e7\u00f5es e discuta o BEYOND-9. Voc\u00ea tamb\u00e9m pode entrar em contato com o centro de estudo mais pr\u00f3ximo para encaminh\u00e1-los.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e28297e e-flex e-con-boxed e-con e-parent\" data-id=\"e28297e\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-cfb6d42 e-con-full e-flex e-con e-child\" data-id=\"cfb6d42\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5be096e elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"5be096e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Encontre um centro de pesquisa perto de voc\u00ea!  <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5d151f9 e-con-full e-flex e-con e-child\" data-id=\"5d151f9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d48539a button-four elementor-widget elementor-widget-button\" data-id=\"d48539a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/pt-br\/am-i-eligible\/#sitefinder\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Ferramenta de localiza\u00e7\u00e3o de centros cl\u00ednicos<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a112ed0 button-four elementor-widget elementor-widget-button\" data-id=\"a112ed0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<style>.elementor-element-a112ed0{display:none !important}<\/style>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6ada0e4 e-flex e-con-boxed e-con e-parent\" data-id=\"6ada0e4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4906787 elementor-widget elementor-widget-text-editor\" data-id=\"4906787\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tA sa\u00fade e a seguran\u00e7a do seu paciente s\u00e3o nossas principais prioridades. Esperamos que voc\u00ea compreenda o impacto gerado por esta pesquisa e considere a possibilidade de indicar potenciais participantes. Com o seu apoio, esperamos ajudar os pacientes com hemofilia B. \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Caring for patients with hemophilia B? Talk to your patients about BEYOND-9 Clinicaltrials.gov euclinicaltrials.eu With no cure for hemophilia B, the BEYOND-9 clinical research study is currently underway to investigate potential long-term treatment options that may benefit both adults and children. Consider BEYOND-9 as an opportunity for your patients with hemophilia B to access investigational [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-22","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/hemophilia-beyond-9.com\/pt-br\/wp-json\/wp\/v2\/pages\/22","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hemophilia-beyond-9.com\/pt-br\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/hemophilia-beyond-9.com\/pt-br\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/hemophilia-beyond-9.com\/pt-br\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hemophilia-beyond-9.com\/pt-br\/wp-json\/wp\/v2\/comments?post=22"}],"version-history":[{"count":0,"href":"https:\/\/hemophilia-beyond-9.com\/pt-br\/wp-json\/wp\/v2\/pages\/22\/revisions"}],"wp:attachment":[{"href":"https:\/\/hemophilia-beyond-9.com\/pt-br\/wp-json\/wp\/v2\/media?parent=22"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}