{"id":22,"date":"2024-06-06T18:04:56","date_gmt":"2024-06-06T18:04:56","guid":{"rendered":"https:\/\/stgbeyond9.wpenginepowered.com\/?page_id=22"},"modified":"2025-11-24T11:59:26","modified_gmt":"2025-11-24T11:59:26","slug":"hcp","status":"publish","type":"page","link":"https:\/\/hemophilia-beyond-9.com\/fr-fr\/hcp\/","title":{"rendered":"Pour les professionnels de sant\u00e9"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"22\" class=\"elementor elementor-22\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8afc29f header-background e-flex e-con-boxed e-con e-parent\" data-id=\"8afc29f\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-1c1aceb e-flex e-con-boxed e-con e-child\" data-id=\"1c1aceb\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f9db144 elementor-widget elementor-widget-heading\" data-id=\"f9db144\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Vous soignez des patients atteints d\u2019h\u00e9mophilie\u202fB\u202f?<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1e4687c elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"1e4687c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>Parlez \u00e0 vos patients de l\u2019\u00e9tude BEYOND-9<\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6edad58 elementor-mobile-align-center button-one elementor-widget elementor-widget-button\" data-id=\"6edad58\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"http:\/\/www.clinicaltrials.gov\/study\/NCT06379789\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Clinicaltrials.gov<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-09cc1f6 button-two elementor-widget elementor-widget-button\" data-id=\"09cc1f6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/euclinicaltrials.eu\/search-for-clinical-trials\/?lang=en&#038;EUCT=2023-507260-40-00\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">euclinicaltrials.eu<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-26eb911 e-flex e-con-boxed e-con e-child\" data-id=\"26eb911\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c08ea34 background-left e-flex e-con-boxed e-con e-parent\" data-id=\"c08ea34\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c89555c e-con-full e-flex e-con e-child\" data-id=\"c89555c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6019c2d elementor-widget elementor-widget-image\" data-id=\"6019c2d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"298\" height=\"244\" src=\"https:\/\/hemophilia-beyond-9.com\/wp-content\/uploads\/2024\/08\/HCPFirst.svg\" class=\"attachment-full size-full wp-image-263\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d24850f e-con-full e-flex e-con e-child\" data-id=\"d24850f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5e2030f elementor-widget elementor-widget-text-editor\" data-id=\"5e2030f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tL\u2019h\u00e9mophilie\u202fB \u00e9tant incurable, l\u2019\u00e9tude de recherche clinique BEYOND-9 est en cours pour \u00e9tudier les options th\u00e9rapeutiques potentielles \u00e0 long terme qui pourraient b\u00e9n\u00e9ficier aux adultes et aux enfants. Consid\u00e9rez l\u2019\u00e9tude BEYOND-9 comme une opportunit\u00e9 pour vos patients atteints d\u2019h\u00e9mophilie\u202fB d\u2019acc\u00e9der \u00e0 des traitements exp\u00e9rimentaux.\n\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-13b7af5 elementor-widget elementor-widget-text-editor\" data-id=\"13b7af5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tL\u2019\u00e9tude BEYOND-9 est la premi\u00e8re \u00e9tude de phase\u202fI\/II men\u00e9e chez l\u2019\u00eatre humain (FIH) visant \u00e0 \u00e9valuer la s\u00e9curit\u00e9, la tol\u00e9rabilit\u00e9, la pharmacocin\u00e9tique (PK) et la pharmacodynamique (PD) d\u2019un traitement exp\u00e9rimental chez des participants atteints d\u2019h\u00e9mophilie\u202fB cong\u00e9nitale s\u00e9v\u00e8re et mod\u00e9r\u00e9ment s\u00e9v\u00e8re, et pr\u00e9sentant une activit\u00e9 fonctionnelle du FIX \u2264\u202f2\u202f%.\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-660ab70 e-flex e-con-boxed e-con e-parent\" data-id=\"660ab70\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-32d55b6 elementor-widget elementor-widget-text-editor\" data-id=\"32d55b6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tLe traitement \u00e0 l\u2019\u00e9tude est une th\u00e9rapie par introduction de g\u00e8ne exp\u00e9rimentale bas\u00e9e sur le syst\u00e8me de r\u00e9p\u00e9titions palindromiques courtes group\u00e9es et r\u00e9guli\u00e8rement espac\u00e9es (CRISPR)\/la prot\u00e9ine\u202f9 associ\u00e9e au CRISPR (Cas9). Il comprend 2\u202fcomposants \u00e0 administrer en une seule fois, par perfusion intraveineuse syst\u00e9mique s\u00e9quentielle.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a7757b3 e-flex e-con-boxed e-con e-parent\" data-id=\"a7757b3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3959521 e-flex e-con-boxed e-con e-child\" data-id=\"3959521\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-41f48f4 e-flex e-con-boxed e-con e-child\" data-id=\"41f48f4\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3296e49 elementor-widget elementor-widget-image\" data-id=\"3296e49\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"102\" height=\"102\" src=\"https:\/\/hemophilia-beyond-9.com\/wp-content\/uploads\/2024\/08\/One.svg\" class=\"attachment-full size-full wp-image-218\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b724cb8 e-flex e-con-boxed e-con e-child\" data-id=\"b724cb8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ff3412f elementor-widget elementor-widget-text-editor\" data-id=\"ff3412f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><span><\/span><\/strong> Le <b>composant\u202f1<\/b> contient un g\u00e8ne d\u2019ADN F9 sans promoteur codant pour la prot\u00e9ine\u202fFIX humaine de type sauvage, d\u00e9livr\u00e9 par le virus ad\u00e9no-associ\u00e9 recombinant de s\u00e9rotype\u202f8 (rAAV8). La matrice d\u2019ADN F9 est ins\u00e9r\u00e9e \u00e0 l\u2019endroit o\u00f9 s\u2019est produite la cassure double brin de l\u2019ADN (DSB) et est transcrite sous l\u2019influence du promoteur endog\u00e8ne de l\u2019albumine (ALB), ce qui entra\u00eene l\u2019expression de la prot\u00e9ine\u202fFIX humaine de type sauvage et sa s\u00e9cr\u00e9tion par le foie.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f434fc2 e-con-full e-flex e-con e-child\" data-id=\"f434fc2\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-af16cda elementor-widget elementor-widget-image\" data-id=\"af16cda\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"102\" height=\"102\" src=\"https:\/\/hemophilia-beyond-9.com\/wp-content\/uploads\/2024\/08\/Two.svg\" class=\"attachment-full size-full wp-image-219\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-839173b e-flex e-con-boxed e-con e-child\" data-id=\"839173b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-864a6d5 elementor-widget elementor-widget-text-editor\" data-id=\"864a6d5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong><span><\/span><\/strong> Le <b>composant\u202f2 <\/b> utilise une technologie modulaire de nanoparticules lipidiques (LNP) pour d\u00e9livrer aux h\u00e9patocytes l\u2019ARN guide unique (sgRNA) ciblant l\u2019ALB et l\u2019ARNm codant pour l\u2019endonucl\u00e9ase Cas9 guid\u00e9e par l\u2019ARN, ce qui permet d\u2019introduire une DSB sp\u00e9cifique dans le premier intron du locus de l\u2019ALB.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6dc33b2 resourcepdf e-flex e-con-boxed e-con e-parent\" data-id=\"6dc33b2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3627afd e-grid e-con-full e-con e-child\" data-id=\"3627afd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3fd4e8c elementor-widget elementor-widget-heading\" data-id=\"3fd4e8c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">En savoir plus<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7a141d9 e-con-full e-flex e-con e-child\" data-id=\"7a141d9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-722e898 elementor-widget elementor-widget-image\" data-id=\"722e898\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"#elementor-action%3Aaction%3Dpopup%3Aopen%26settings%3DeyJpZCI6IjQwMiIsInRvZ2dsZSI6ZmFsc2V9\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1183\" height=\"678\" src=\"\/wp-content\/uploads\/2025\/11\/French-HCP-1.png\" class=\"attachment-full size-full wp-image-461\" alt=\"\" srcset=\"\" sizes=\"(max-width: 1183px) 100vw, 1183px\" data-srcset=\"\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b56a55f elementor-align-center elementor-mobile-align-center elementor-widget elementor-widget-button\" data-id=\"b56a55f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/wp-content\/uploads\/2025\/08\/HSCI-P00102043-HCP-Infographic-16_fr-FR-1.pdf\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">T\u00e9l\u00e9charger<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-39407ae background-right e-flex e-con-boxed e-con e-parent\" data-id=\"39407ae\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-dfc2dd5 e-con-full e-flex e-con e-child\" data-id=\"dfc2dd5\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3c6c31b elementor-widget elementor-widget-text-editor\" data-id=\"3c6c31b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tLa participation des patients \u00e0 cette \u00e9tude devrait durer jusqu\u2019\u00e0 environ 2\u202fans et 8\u202fmois. La participation peut durer plus longtemps (jusqu\u2019\u00e0 4\u202fans et 2\u202fmois) en fonction du temps pass\u00e9 dans la p\u00e9riode pr\u00e9liminaire.\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38e0e7b elementor-widget elementor-widget-text-editor\" data-id=\"38e0e7b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tLes participants seront rembours\u00e9s de leurs frais de d\u00e9placement raisonnables li\u00e9s aux visites de l\u2019\u00e9tude, et les soins m\u00e9dicaux associ\u00e9s \u00e0 leur participation, y compris le traitement \u00e0 l\u2019\u00e9tude, seront fournis gratuitement. \n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e399a6c button-three elementor-mobile-align-center elementor-widget elementor-widget-button\" data-id=\"e399a6c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/fr-fr\/about-beyond-9\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">\u00c0 propos de l\u2019\u00e9tude BEYOND-9<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c57d058 e-con-full e-flex e-con e-child\" data-id=\"c57d058\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-386f258 elementor-widget elementor-widget-image\" data-id=\"386f258\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"470\" height=\"319\" src=\"https:\/\/hemophilia-beyond-9.com\/wp-content\/uploads\/2024\/08\/HCPAbout.svg\" class=\"attachment-full size-full wp-image-264\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-058138c e-flex e-con-boxed e-con e-parent\" data-id=\"058138c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-96593d7 elementor-widget elementor-widget-heading\" data-id=\"96593d7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Comment pouvez-vous apporter votre aide\u202f?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3948946 elementor-widget elementor-widget-text-editor\" data-id=\"3948946\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tL\u2019\u00e9tude BEYOND-9 recrute jusqu\u2019\u00e0 environ 120\u202fpersonnes dans une dizaine de pays \u00e0 travers le monde. Le succ\u00e8s de l\u2019\u00e9tude BEYOND-9 repose sur les m\u00e9decins qui recommandent des participants potentiellement admissibles. Veuillez consulter ci-dessous les principaux crit\u00e8res de l\u2019\u00e9tude pour identifier les candidats potentiels.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-eb26836 e-flex e-con-boxed e-con e-parent\" data-id=\"eb26836\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3718095 e-flex e-con-boxed e-con e-child\" data-id=\"3718095\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-b556b2d e-flex e-con-boxed e-con e-child\" data-id=\"b556b2d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c65d268 elementor-widget elementor-widget-image\" data-id=\"c65d268\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"76\" height=\"77\" src=\"https:\/\/hemophilia-beyond-9.com\/wp-content\/uploads\/2024\/08\/Tick.svg\" class=\"attachment-full size-full wp-image-222\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-46c7386 e-flex e-con-boxed e-con e-child\" data-id=\"46c7386\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f55b0ea elementor-widget elementor-widget-heading\" data-id=\"f55b0ea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Principaux crit\u00e8res d\u2019inclusion\u202f:<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7eff5ff ul-only elementor-widget elementor-widget-text-editor\" data-id=\"7eff5ff\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Homme (\u00e2g\u00e9 de \u2265\u202f18\u202fans)<br \/>REMARQUE\u202f: \u00e0 l\u2019avenir, il est pr\u00e9vu d\u2019inclure des enfants dans l\u2019essai clinique (\u00e2g\u00e9s de 2 \u00e0 17\u202fans)<\/li><li>Diagnostic confirm\u00e9 d\u2019h\u00e9mophilie\u202fB s\u00e9v\u00e8re ou mod\u00e9r\u00e9ment s\u00e9v\u00e8re avec ant\u00e9c\u00e9dents m\u00e9dicaux d\u2019activit\u00e9 fonctionnelle du FIX \u2264\u202f2\u202f% ou &lt;\u202f0,02\u202fUI\/mL<\/li><li>Prise actuelle d\u2019une prophylaxie par FIX et exp\u00e9rience ant\u00e9rieure d\u2019un traitement par FIX\u202f: \u2265\u202f150\u202fjours d\u2019exposition document\u00e9s \u00e0 une prot\u00e9ine FIX, telle qu\u2019un produit recombinant, d\u00e9riv\u00e9 du plasma ou \u00e0 demi-vie prolong\u00e9e<\/li><li>Participation \u00e0 la p\u00e9riode pr\u00e9liminaire de cette \u00e9tude interventionnelle OU \u00e0 une \u00e9tude pr\u00e9liminaire distincte (R0000-HEMB-2187) pendant au moins 6\u202fmois pour la collecte de donn\u00e9es ABR pendant la prophylaxie par FIX.<br \/>REMARQUE\u202f: les trois premiers participants inclus dans la Partie\u202f1 de l\u2019\u00e9tude ne sont pas tenus de participer \u00e0 la p\u00e9riode pr\u00e9liminaire.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d32c571 e-con-full e-flex e-con e-child\" data-id=\"d32c571\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ac78d28 elementor-widget elementor-widget-image\" data-id=\"ac78d28\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"76\" height=\"76\" src=\"https:\/\/hemophilia-beyond-9.com\/wp-content\/uploads\/2024\/08\/X.svg\" class=\"attachment-full size-full wp-image-223\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e4c2313 e-flex e-con-boxed e-con e-child\" data-id=\"e4c2313\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f29b377 elementor-widget elementor-widget-heading\" data-id=\"f29b377\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Principaux crit\u00e8res de non-inclusion\u202f:<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-636ec4e ul-only elementor-widget elementor-widget-text-editor\" data-id=\"636ec4e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Ant\u00e9c\u00e9dents d\u2019inhibiteurs du FIX (\u00e9valuation clinique ou en laboratoire) \u00e0 deux reprises ou plus\u202f<\/li><li>Titre d\u2019inhibiteur Bethesda sup\u00e9rieur \u00e0 la limite sup\u00e9rieure de la normale (LSN) lors de la s\u00e9lection\u202f\u202f<\/li><li>Anticorps pr\u00e9existants d\u00e9tectables contre la capside de l\u2019AAV8, mesur\u00e9s par un test ELISA lors de la pr\u00e9-s\u00e9lection (ou de la visite pr\u00e9liminaire finale, le cas \u00e9ch\u00e9ant)<\/li><li>Un participant n\u2019est pas admissible si l\u2019un des diagnostics pr\u00e9existants suivants, \u00e9vocateurs d\u2019une maladie h\u00e9patique sous-jacente importante, est document\u00e9\u202f:\u202f\u202f<ul><li>Maladie cholestatique du foie\u202f\u202f<\/li><li>Cirrhose du foie\u202f\u202f<\/li><li>Hypertension portale\u202f\u202f<\/li><li>Spl\u00e9nom\u00e9galie\u202f\u202f<\/li><li>Enc\u00e9phalopathie h\u00e9patique\u202f\u202f<\/li><\/ul><\/li><li>Preuve d\u2019une fibrose h\u00e9patique avanc\u00e9e sugg\u00e9rant une maladie de stade\u202f3 selon le score histologique de M\u00e9tavir ou \u00e9quivalente lors de la s\u00e9lection (c\u2019est-\u00e0-dire, mesure de la rigidit\u00e9 du foie \u2265\u202f9\u202fkPa), mesur\u00e9e par \u00e9lastographie transitoire (FibroScan) lors de la s\u00e9lection ou mesur\u00e9e dans les 6\u202fmois pr\u00e9c\u00e9dant la visite de s\u00e9lection<\/li><li>Preuve de cirrhose et\/ou d\u2019hypertension portale \u00e9valu\u00e9e par \u00e9chographie h\u00e9patique lors de la s\u00e9lection ou mesur\u00e9e dans les 6\u202fmois pr\u00e9c\u00e9dant la visite de s\u00e9lection\u202f<\/li><li>Ant\u00e9c\u00e9dents d\u2019\u00e9v\u00e9nements thrombo-emboliques art\u00e9riels ou veineux, y compris, mais sans s\u2019y limiter, accident vasculaire c\u00e9r\u00e9bral non h\u00e9morragique, infarctus du myocarde, embolie art\u00e9rielle, thrombose veineuse profonde, embolie pulmonaire, \u00e0 l\u2019exception d\u2019une thrombose associ\u00e9e \u00e0 un cath\u00e9ter pour laquelle un traitement antithrombotique n\u2019est pas en cours<\/li><li>Ant\u00e9c\u00e9dents d\u2019hypersensibilit\u00e9 aux cortico\u00efdes ou \u00e9tat pathologique connu \n\nn\u00e9cessitant l\u2019administration chronique de cortico\u00efdes<\/li><li>Avoir d\u00e9j\u00e0 re\u00e7u une th\u00e9rapie g\u00e9nique \u00e0 base d\u2019AAV avec une th\u00e9rapie g\u00e9nique commercialis\u00e9e ou dans le cadre d\u2019un essai clinique, ou avoir l\u2019intention de recevoir une th\u00e9rapie g\u00e9nique \u00e0 base d\u2019AAV approuv\u00e9e ou exp\u00e9rimentale autre que le traitement \u00e0 l\u2019\u00e9tude pendant la p\u00e9riode de l\u2019\u00e9tude<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3e8c3e4 e-flex e-con-boxed e-con e-parent\" data-id=\"3e8c3e4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3458326 e-con-full e-flex e-con e-child\" data-id=\"3458326\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9c046b0 elementor-widget elementor-widget-image\" data-id=\"9c046b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"94\" height=\"137\" src=\"https:\/\/hemophilia-beyond-9.com\/wp-content\/uploads\/2024\/08\/HCPicon.svg\" class=\"attachment-full size-full wp-image-245\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-07d7d1f e-flex e-con-boxed e-con e-child\" data-id=\"07d7d1f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2406c67 elementor-widget elementor-widget-text-editor\" data-id=\"2406c67\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Remarque:<\/strong> d\u2019autres crit\u00e8res d\u2019inclusion\/exclusion d\u00e9finis par le protocole s\u2019appliquent.\u202f\u202f\u00a0\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1939f17 elementor-widget elementor-widget-text-editor\" data-id=\"1939f17\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>L\u2019\u00e9quipe charg\u00e9e de l\u2019\u00e9tude examinera l\u2019ensemble des ant\u00e9c\u00e9dents m\u00e9dicaux de votre patient pour v\u00e9rifier s\u2019il r\u00e9pond \u00e0 tous les crit\u00e8res d\u2019inclusion et \u00e0 aucun des crit\u00e8res d\u2019exclusion. Dans les \u00e9tudes cliniques, la diversit\u00e9 est essentielle au d\u00e9veloppement de meilleurs traitements. Aidez-nous \u00e0 faire en sorte que vos patients soient repr\u00e9sent\u00e9s.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ce474a4 e-flex e-con-boxed e-con e-parent\" data-id=\"ce474a4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-679f051 e-flex e-con-boxed e-con e-child\" data-id=\"679f051\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fea662c elementor-widget elementor-widget-text-editor\" data-id=\"fea662c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tSi vous avez des patients potentiellement admissibles et int\u00e9ress\u00e9s, augmentez leurs chances de succ\u00e8s en leur parlant de l\u2019\u00e9tude BEYOND-9. Vous pouvez \u00e9galement contacter le centre d\u2019\u00e9tude le plus proche pour les y orienter.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e28297e e-flex e-con-boxed e-con e-parent\" data-id=\"e28297e\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-cfb6d42 e-con-full e-flex e-con e-child\" data-id=\"cfb6d42\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5be096e elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"5be096e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Trouvez un centre d\u2019\u00e9tude pr\u00e8s de chez vous\u202f!  <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5d151f9 e-con-full e-flex e-con e-child\" data-id=\"5d151f9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d48539a button-four elementor-widget elementor-widget-button\" data-id=\"d48539a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"\/fr-fr\/am-i-eligible\/#sitefinder\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Localisateur de centre<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a112ed0 button-four elementor-widget elementor-widget-button\" data-id=\"a112ed0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<style>.elementor-element-a112ed0{display:none !important}<\/style>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6ada0e4 e-flex e-con-boxed e-con e-parent\" data-id=\"6ada0e4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4906787 elementor-widget elementor-widget-text-editor\" data-id=\"4906787\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tLa sant\u00e9 et la s\u00e9curit\u00e9 de vos patients constituent nos priorit\u00e9s absolues. Nous esp\u00e9rons que vous comprendrez l\u2019importance de cette \u00e9tude et que vous envisagerez de nous adresser des candidats potentiels. Gr\u00e2ce \u00e0 votre soutien, nous esp\u00e9rons aider les patients atteints d\u2019h\u00e9mophilie\u202fB. \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Caring for patients with hemophilia B? Talk to your patients about BEYOND-9 Clinicaltrials.gov euclinicaltrials.eu With no cure for hemophilia B, the BEYOND-9 clinical research study is currently underway to investigate potential long-term treatment options that may benefit both adults and children. Consider BEYOND-9 as an opportunity for your patients with hemophilia B to access investigational [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-22","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/hemophilia-beyond-9.com\/fr-fr\/wp-json\/wp\/v2\/pages\/22","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hemophilia-beyond-9.com\/fr-fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/hemophilia-beyond-9.com\/fr-fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/hemophilia-beyond-9.com\/fr-fr\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hemophilia-beyond-9.com\/fr-fr\/wp-json\/wp\/v2\/comments?post=22"}],"version-history":[{"count":0,"href":"https:\/\/hemophilia-beyond-9.com\/fr-fr\/wp-json\/wp\/v2\/pages\/22\/revisions"}],"wp:attachment":[{"href":"https:\/\/hemophilia-beyond-9.com\/fr-fr\/wp-json\/wp\/v2\/media?parent=22"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}